RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
mir-133a-1
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
NA
Target
TGF-B
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
MiR-133a mediates TGF-B-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis
Year
2013
Function
"The total mir-133a expression level remained unchanged in total rna extracts from fibrotic and human liver. However, mir-133a was specifically down-regulated in hsc during fibrogenesis. In turn, overexpression of mir-133a in primary mouse hsc leads to a decrease in collagen expression. Indicating that mir-33a has anti-fibrosis effect."